WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:DNA replication       ID:03030
C=36; O=4; E=0.13; R=31.53; rawP=8.00e-06; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105486 NA LIG1 ligase I, DNA, ATP-dependent 3978 ENSG00000105486
2  ENSG00000014138 NA POLA2 polymerase (DNA directed), alpha 2, accessory subunit 23649 ENSG00000014138
3  ENSG00000166508 NA MCM7 minichromosome maintenance complex component 7 4176 ENSG00000166508
4  ENSG00000100297 NA MCM5 minichromosome maintenance complex component 5 4174 ENSG00000100297


Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=5; E=0.44; R=11.44; rawP=8.18e-05; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000055130 NA CUL1 cullin 1 8454 ENSG00000055130
2  ENSG00000101224 NA CDC25B cell division cycle 25 homolog B (S. pombe) 994 ENSG00000101224
3  ENSG00000166508 NA MCM7 minichromosome maintenance complex component 7 4176 ENSG00000166508
4  ENSG00000100297 NA MCM5 minichromosome maintenance complex component 5 4174 ENSG00000100297
5  ENSG00000145604 NA SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 6502 ENSG00000145604


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=6; E=0.94; R=6.35; rawP=0.0004; adjP=0.0043
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000087095 NA NLK nemo-like kinase 51701 ENSG00000087095
2  ENSG00000101224 NA CDC25B cell division cycle 25 homolog B (S. pombe) 994 ENSG00000101224
3  ENSG00000151062 NA CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 93589 ENSG00000151062
4  ENSG00000139625 NA MAP3K12 mitogen-activated protein kinase kinase kinase 12 7786 ENSG00000139625
5  ENSG00000132155 NA RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 5894 ENSG00000132155
6  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365


Database:KEGG pathway       Name:Hepatitis C       ID:05160
C=134; O=4; E=0.47; R=8.47; rawP=0.0013; adjP=0.0104
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
2  ENSG00000132155 NA RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 5894 ENSG00000132155
3  ENSG00000181885 NA CLDN7 claudin 7 1366 ENSG00000181885
4  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365


Database:KEGG pathway       Name:Small cell lung cancer       ID:05222
C=85; O=3; E=0.30; R=10.01; rawP=0.0034; adjP=0.0181
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
2  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
3  ENSG00000145604 NA SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 6502 ENSG00000145604


Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=3; E=0.30; R=10.13; rawP=0.0033; adjP=0.0181
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000090539 NA CHRD chordin 8646 ENSG00000090539
2  ENSG00000055130 NA CUL1 cullin 1 8454 ENSG00000055130
3  ENSG00000169231 NA THBS3 thrombospondin 3 7059 ENSG00000169231


Database:KEGG pathway       Name:Amino sugar and nucleotide sugar metabolism       ID:00520
C=48; O=2; E=0.17; R=11.82; rawP=0.0125; adjP=0.0500
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162066 NA AMDHD2 amidohydrolase domain containing 2 51005 ENSG00000162066
2  ENSG00000124357 NA NAGK N-acetylglucosamine kinase 55577 ENSG00000124357


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=3; E=0.48; R=6.31; rawP=0.0123; adjP=0.0500
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
2  ENSG00000055130 NA CUL1 cullin 1 8454 ENSG00000055130
3  ENSG00000145604 NA SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 6502 ENSG00000145604


Database:KEGG pathway       Name:RIG-I-like receptor signaling pathway       ID:04622
C=71; O=2; E=0.25; R=7.99; rawP=0.0262; adjP=0.0532
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000184584 NA TMEM173 transmembrane protein 173 340061 ENSG00000184584
2  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365


Database:KEGG pathway       Name:Cytosolic DNA-sensing pathway       ID:04623
C=56; O=2; E=0.20; R=10.13; rawP=0.0168; adjP=0.0532
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000184584 NA TMEM173 transmembrane protein 173 340061 ENSG00000184584
2  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).